Critical care units are high-risk areas which contribute to increased health care costs and increased patient morbidity and mortality. Patients in critical care units are commonly confronted with existing and the potential to develop infections. Critical care practitioners play a crucial role as initial providers to critically ill patients with infections through the delivery of timely and appropriate therapies aimed to prevent and treat patient infections. The responsibility of critical care practitioners include prudent delivery of care to treat current infections as well as ensuring the delivery of care does not increase the development of new infections. Aggressive infection control measures are needed to reduce infections in critical care settings. Dissemination of scholarly work on the topic of infection in critically ill patients can play a role in improving patient outcomes. The information provided on infections in this issue of Critical Care Nursing Clinics promotes the dissemination of current literature on a series of timely and relevant infection topics in critical care environments.