This issue of Thoracic Surgery Clinics, guest edited by Dr. Pier Luigi Filosso, is devoted to Clinical Management of Chest Tubes. Dr. Filosso has assembled expert authors to review the following topics: Chest Tubes Throughout the Centuries: An Overview of Pleural Space Drainage Across History; Generalities of Chest Tubes; Chest Tube Placement After Pulmonary Resection; Thoracic Trauma: Which Chest Tube?; Chest Tube Placement in Pleural Effusions and Pneumothorax; Modern Techniques to Insert Chest Tubes; Suction or Non-suction?: How to Manage a Chest Tube After Pulmonary Resection; When to Remove a Chest Tube?; Indwelling Pleural Catheters: A Clinical Option in Trapped Lung; Errors in Chest Tube Placement; and more!