Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. * Covers both basic science and applied technology / methods * Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects * Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development * Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria