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Mitochondrial Disorders Caused by Nuclear Genes

Edited by Lee-Jun C. Wong
Format: Paperback / softback
Publisher: Springer-Verlag New York Inc., New York, United States
Published: 15th Oct 2014
Dimensions: w 156mm h 234mm d 20mm
Weight: 538g
ISBN-10: 1489992413
ISBN-13: 9781489992413
Barcode No: 9781489992413
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Synopsis
Mitochondrial cytopathies are mutations in the inherited maternal mitochondrial genome, or the nuclear DNA-mutation. Mitochondrial respiratory chain disorders (RCD) are a group of genetically and clinically heterogeneous diseases, due to the fact that protein components of the respiratory chain are encoded by both mitochondrial and nuclear genomes and are essential in all cells. In addition, the biogenesis, structure and function of mitochondria, including DNA replication, transcription, and translation, all require nuclear encoded genes. Since mitochondria are present in every cell, every tissue, mitochondrial disorder usually affects multiple organs.

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