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Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy

Resistance to Targeted Anti-Cancer Therapeutics 9

Edited by Emmanuel Donnadieu
Format: Hardback
Publisher: Springer International Publishing AG, Cham, Switzerland
Published: 6th Sep 2016
Dimensions: w 156mm h 234mm d 13mm
Weight: 471g
ISBN-10: 3319422219
ISBN-13: 9783319422213
Barcode No: 9783319422213
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Synopsis
This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.

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