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The Role of Pendrin in Health and Disease

Molecular and Functional Aspects of the SLC26A4 Anion Exchanger

Format: Hardback
Publisher: Springer International Publishing AG, Cham, Switzerland
Published: 10th Mar 2017
Dimensions: w 155mm h 235mm d 20mm
Weight: 4784g
ISBN-10: 3319432850
ISBN-13: 9783319432854
Barcode No: 9783319432854
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Synopsis
This book reviews the current state of knowledge on the genetics, molecular biology and physiology of pendrin, with a particular focus on pendrin dysfunction and the consequences for human health. Pendrin is a membrane transport protein expressed in the thyroid, inner ear, kidney and airways, and was recently found in a variety of other tissues and organs. Pendrin malfunction may cause a genetic disease called Pendred syndrome or non-syndromic deafness. The book provides a thorough description of the multifaceted role of pendrin in human health and disease. As such, it offers an invaluable tool for physiology and pathology researchers, while also providing essential guidance for otorhinolaryngologists and endocrinologists in the diagnosis of Pendred syndrome and pendrin-related deafness.

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"The purpose is to summarize the current knowledge about the role of pendrin in normal physiology and disease pathology. The intended audience is predominantly researchers and physicians interested in a detailed description of the multifaceted function of pendrin. However, the book also could serve as a good source for undergraduate and graduate students and postgraduate trainees interested in thyroid physiology and pathology as well as physiology, pathology, and diagnosis of deafness in general." (Partha Kasturi, Doody's Book Reviews, June, 2017)