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The Blood Brain Barrier and Inflammation

Progress in Inflammation Research

Edited by Gaby Enzmann, Ruth Lyck
Format: Hardback
Publisher: Springer International Publishing AG, Cham, Switzerland
Published: 10th Apr 2017
Dimensions: w 155mm h 235mm d 21mm
Weight: 5608g
ISBN-10: 3319455125
ISBN-13: 9783319455129
Barcode No: 9783319455129
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Synopsis
This PIR volume presents a comprehensive collection of reviews that focus on the role of the blood-brain barrier (BBB) during steady-state and inflamed conditions. Within the central nervous system (CNS) the constantly changing bloodstream is strictly separated from the CNS parenchyma by the BBB. However, viruses, bacteria, parasites and auto-aggressive immune cells can penetrate the barrier and significantly contribute to CNS inflammation. The BBB can actively contribute to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alterations of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential to the development of new drugs to efficiently combat inflammatory diseases of the CNS.

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