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Sigma Receptors: Their Role in Disease and as Therapeutic Targets

Advances in Experimental Medicine and Biology 964

Format: Hardback
Publisher: Springer International Publishing AG, Cham, Switzerland
Published: 27th Mar 2017
Dimensions: w 178mm h 254mm d 24mm
Weight: 8349g
ISBN-10: 3319501720
ISBN-13: 9783319501727
Barcode No: 9783319501727
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Synopsis
Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types. It's putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, Huntington's disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors. Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.

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