This book is a critical and multidisciplinary IPE of the unequal structures of South American development and uneven insertions in the global order following the decline of the commodities boom. The work explores the extent to which regional development issues are related to merely a decline of commodities prices and/or to the resilience of the historical structures within an unequal world order. Thus, the authors seek first to analytically explore the regional issues beyond the formal limitations of North American and Eurocentric approaches. Secondly, they empirically scrutinize the complex dimensions of regional inequality and global insertions. Aspects analysed include economic reprimarization, the impact of China, development finance, trade and regional value chains, knowledge and technology, regional and transnational organised crime, cities, economic integration and the Global South.