Papyrus Leiden I 343 + 345 is one of the most extraordinary manuscripts providing a deeper insight into magic and medicine in Ancient Egypt. The main part of the papyrus deals with the ancient Near Eastern disease demon Samanu, who is well known from Sumerian and Akkadian incantations and medical texts. In addition, a broad range of other conjurations and spells against any pain and feet swelling are included. The papyrus also contains two curious spells dealing with 'falling water from the sky'. Eight out of fourteen incantations against the demon Samanu were incorporated twice in this papyrus. The texts are not only presented as parallel text edition but also with photographs of the papyrus. This re-edition of papyrus Leiden I 343 + 345 is a revised transliteration, transcription, translation and up-to-date commentary.