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Oncogenes as Transcriptional Regulators

Retrovial Oncogenes v. 1. Progress in Gene Expression

Format: Hardback
Publisher: Birkhauser Verlag AG, Basel, Switzerland
Published: 31st May 1997
Dimensions: w 155mm h 235mm
ISBN-10: 3764354860
ISBN-13: 9783764354862
Barcode No: 9783764354862
The study of the molecular events leading to cellular transformation and cancer has progressed significantly in the last decade, and it has become apparent that many genes subject to modification in cancer are, in fact, transcription factors that govern the execution of the genetic programme of the cell. Transcription factors can behave either as oncogenes or as tumour suppressor genes. To date only a limited number of transcription factors have been associated with cancer. This volume deals with several transcription factor families that were first identified in oncogenic retroviruses. Each chapter contains a description of the structure of the transcription factors, the nature of target genes, the regulation of their activities, and an explaination of how they can deregulate cell growth and differentiation. This text should be suitable for the specialist scientist and the advanced student

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