Physicians struggle between the desire to be part of a competitive healthcare system and the need for autonomy. Many are selling their practices to hospital organizations, healthcare systems, or physician management companies. Others have joined independent practice associations, clinics without walls, modified physician hospital organizations, or specialty networks. Some have formed physician equity groups. To make an informed decision, physicians need to be able to consider the advantages of each of these structures against an increasingly complex demand to market to targeted payors. This is a guide to the organizational options facing physicians, including all of the choices in detail, suggestions on how to market each organizational structure, and examples of successful practices.