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Protein Secretion

A Critical Analysis of the Vesicle Model

By (author) S.S. Rothman
Genres: Proteins
Format: Hardback
Publisher: John Wiley and Sons Ltd, New York, United States
Imprint: John Wiley & Sons Inc
Published: 12th Mar 1986
Dimensions: w 160mm h 240mm
Weight: 680g
ISBN-10: 0471079766
ISBN-13: 9780471079767
Barcode No: 9780471079767
Investigates a new model of protein secretion and challenges the vesicle theory of transport, which is based on the notion that protein molecules can not pass through biological membranes or through channels within them. The book develops a diffusion-based model of transport, known as the equilibrium theory, which views the secretion of protein as an integral part of the study of biological transport. It discusses the general context for the vesicle paradigm, describes the paradigm and critically examines its assumptions (viz, the impermeability of membranes to proteins, the filling of secretion granules with product, the exocytosis model of secretion, and the signal hypothesis), and goes on to review a variety of experimental tests of the paradigm, considering these from the viewpoint of the diffusion-based theory of transport.

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