This study describes a project carried out working with Quaker meetings around Britain. Using questionnaires, discussions and case histories, participants explored their approaches to ethical and theological issues in genetic manipulation, including genetic testing, disclosure of genetic information, patenting and attitudes to variation and disability. Going beyond a straightforward account of opinions, the work uncovered the moral and spiritual values on which those opinions were based. Finally, the text considers the processes people use to make moral evaluations, especially in unfamiliar territory, and how this could be improved. It should be of interest to both Quakers and non-Quakers concerned about the impact of the new genetics and moral competence.