The Handbook on regulatory frameworks for the control and eradication of HPAI and other transboundary animal diseases adopts the principles and approach of One Health by creating an understanding of the context in which diseases emerge, and by presenting the two key issues - legislation and regulatory frameworks - for the attention of administrators and policy-makers. The Handbook explains the critical role of regulatory frameworks (policy and institutional) on animal health and the need for close cooperation within countries between people who have technical veterinary expertise and those who have legal and regulatory expertise. It further defines the structure and elements of veterinary policy and legislation, the international frame of reference, the interface between veterinary policy, institutions and legislation, and the potential impacts of the national legal tradition on the way that laws are drafted specifically on animal health matters.