Despite the extensive worldwide use of non-narcotic analgesics, such as acetylsalicylic acid (ASA), paracetamol and dipyrone, gaps still exist in our understanding of their actions, as well as misconceptions about their safety and clinical applications. Recent studies have revealed potential new sites of action. In addition, long-term toxicological and epidemiological investigations with dipyrone and ASA have brought the safety of these drugs into clearer perspective. This book contains contributions from internationally reputed experts and provides both a comprehensive update on the facts. and a balanced discussion of their implications for the continued use of non-narcotic analgesics.