Globalization is changing the nature of business. As more and more markets open up, management strategies have to adapt to these changes. This work focuses on the economic and environmental changes that are affecting businesses. It sets out eight trends (low price segmentation, fragmentation, robotization, acceleration of productive innovation, globalization, transnational competition, liberalization of world trade and deregulation) and demonstrates how companies need to take account of these to ensure survival. While small companies and the large multinationals are more able to adapt - they can develop strategic alliances - medium-sized companies will have to look more closely at how they operate to survive in the 21st century.