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Computer Techniques in Preclinical and Clinical Drug Development

By (author) Robert C. Jackson
Format: Paperback / softback
Publisher: Taylor & Francis Ltd, London, United Kingdom
Imprint: CRC Press
Published: 7th Oct 2019
Dimensions: w 156mm h 234mm d 14mm
Weight: 470g
ISBN-10: 0367401282
ISBN-13: 9780367401283
Barcode No: 9780367401283
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Synopsis
It is estimated that 80 to 90% of drugs under development never make it to the marketplace due to insufficient clinical activity, unacceptable toxicity, rapid appearance of drug resistance, or other factors that should be, at least partially, predictable from preclinical testing. This new text asks the question, "How can we use computational methods to improve the success rate in drug development?" Computer Techniques in Preclinical and Clinical Drug Development shows how modeling makes it possible to extract the maximum amount of information and predictive value from preclinical data. Computer modeling methods from the areas of pharmacokinetics, pharmacodynamics, cytokinetics, and inhibition kinetics of multi-enzyme pathways are all discussed in this unique reference source.

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