This book contains a compilation of the revised and extended versions of the best papers presented at the 16th International Joint Conference on E-Business and Telecommunications, ICETE 2019, held in Prague, Czech Republic, in July 2019. ICETE is a joint international conference integrating four major areas of knowledge that are divided into six corresponding conferences: International Conference on Data Communication Networking, DCNET; International Conference on E-Business, ICE-B; International Conference on Optical Communication Systems, OPTICS; International Conference on Security and Cryptography, SECRYPT; International Conference on Signal Processing and Multimedia, SIGMAP; International Conference on Wireless Information Systems, WINSYS. The 11 full papers presented in the volume were carefully reviewed and selected from the 166 submissions. The papers cover the following key areas of data communication networking, e-business, security and cryptography, signal processing and multimedia applications.